/COMUNICAE/
Synlab has launched a genetic study, INTOLERANCE2, which allows us to know, in a single analysis, whether there is genetic predisposition to celliachia and/or primary intolerance to lactose. The test is performed from a sample of blood or brushed of oral mucosa
This test is particularly recommended in people with clinical suspicion of celiac disease and negative serological study before biopsy is performed, and in those who have symptomatology compatible with celiac disease or lactose intolerance.
Celiac disease affects about 1 per cent of the European population, and is more common in women with a proportion of double than men. In addition, more and more people have digestive discomfort originating after the ingestion of certain foods. Foods most frequently related to these digestive discomforts are foods derived from cereals and dairy.
Celiac disease
Celiachia is due to gluten intolerance, a set of proteins present in most cereals. It is characterized by an inflammatory reaction in the mucosa of the small intestine, caused by an immune response, which makes it difficult to absorb macro and micronutrients. The most common symptoms are weight and appetite loss, fatigue, nausea, vomiting, diarrhea, strain and abdominal pain, muscle mass loss, and growth delay among others. Treatment consists of following a strict gluten-free diet that should continue throughout life. Eliminating gluten from the diet results in clinical and functional normalization, repairing the damage caused in intestinal hair. However, this exclusion diet is complex, as gluten is present in 80% of manufactured solid foods.
Primary intolerance to lactos
Sometimes people have abdominal pain and distention, swelling, gases, and diarrhea, following the use of dairy. These symptoms may be caused by the inability to metabolize lactose, the main sugar of milk. Lactose is hydrolysed in the body through an enzyme called lactasa giving rise to glucose and galactous that are absorbed at the intestinal level. When lactose is not hydrolyzed, it passes to the large intestine causing symptoms.
Primary intolerance to acquired lactose or hypolactasia is the most common cause of lactose intolerance in adults and has a genetic origin. It is estimated that approximately 75 per cent of the population lose the ability to digest lactose at some point in their lives. The loss of activity is associated with age, and a reduction in this activity may be observed from 3-5 years, although it is most common in adulthood.
INTOLERANCE2
The test INTOLERANCE2 allows to know in a single analysis whether there is genetic predisposition to celiacs and/or primary intolerance to lactose. This predisposition is determined by the study of HLA-DQ2 and HLA-DQ8 risk haplotypes. 90% of patients with celiac disease are positive HLA-DQ2 while the rest have allele variants that encode HLA-DQ8 without HLA-DQ2 (6%) or a single HLA-DQ2 allele. Therefore, the absence of the haplotypes studied makes the diagnosis of celiac disease very unlikely.
La intolerance of lactose is determined by the analysis of the promoter region of the LTC gene located in the MCM6 gene. The test INTOLERANCE2 analyzes polymorphism -13910 (rs4988235) in the MCM6 gene, responsible for 90% of cases of primary lactose intolerance in Caucasian population.
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Source Comunicae
A new Synlab test lets you know if there is genetic predisposition to celliachia and lactose intolerance
Synlab has launched a genetic study, INTOLERANCE2, which allows us to know, in a single analysis, whether there is genetic predisposition to celliachia and/or
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2023-04-11
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